Pto DC3000 - Plant Interaction

	P. s. pv. tomato DC3000	P. s. pv. syringae B728a	P. s. pv. phaseolicola 1448A
Pto DC3000 - Plant Interaction			genome resources home page

Genomic analyses are revealing an increasingly complex web of interactions occurring between pathogen and host gene products. Systematic characterizations of these interactions is being modeled using Gene Ontology (GO) Annotation.

Virulence factors with associated GO annotations
(click on hyperlinks for individual Pst DC3000 virulence factors to see the complete list of annotations for each)
Key to modified Gene Ontology Annotation used to describe the Pst DC3000-host interaction
Frequently Asked Questions

Pto DC3000 Hop effector proteins
avrE1	avrPto	avrPtoB (hopAB2)	hopA1
hopB1	hopC1	hopD1	hopE1
hopF2	hopG1	hopH1	hopI1
hopK1	hopM1	hopN1	hopO1-1
hopO1-2	hopQ1-1	hopQ1-2	hopR1
hopS1	hopT1-1	hopT1-2	hopU1
hopV1	hopX1	hopY1	hopAA1-1
hopAA1-2	hopAF1	hopAH1	hopAH2-1
hopAH2-2	hopAI1	hopAM1-1	hopAM1-2
hopAN1	hopAO1	hopAQ1	-
Hop effector proteins (not present in Pto DC3000)
avrA1	avrB1	avrB2	avrRpm1
avrRps4	avrRpt2	hopAB1	hopAR1
Harpins, pilus-associated proteins, and T3SS helpers
hrpA1	hrpH1	hrpK1	hrpW1
hrpZ1	hopP1	hopAJ1	hopAK1
Toxins
coronatine	mangotoxin	phaseolotoxin	-
Pamps
flagellin	LPS	EF-Tu	-

AvrE1 (PSPTO_1377)

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GO term	GO ID	Ontology	Reference	PubMed ID	with	Evidence Code	Host ID	host interaction
host cell	GO:0043657	C	Badel, 2006	16529372	-	IDA	N benth	-
pathogenesis	GO:0009405	P	Badel, 2006	16529372	-	IDA	N tab xanthi	-
			Debroy, 2004	15210989	-	IDA	A thal Col-0	-
			Badel, 2006	16529372	-	IDA	N benth	-
			Badel, 2006	16529372	-	IDA	S. lyco Money maker	-
interaction with host via protein secreted by type III secretion system	GO:0052049	P	Badel, 2006	16529372	-	IDA	N benth	-
positive regulation of growth or development of symbiont during interaction with host	GO:0075339	P	Badel, 2006	16529372	HopM1 Q887D0	IGI	S. lyco Money maker	-
	GO:0075339	P	Debroy, 2004	15210989	-	IDA	A thal Col-0	-
killing by symbiont of host cells	GO:0001907	P	Badel, 2006	16529372	-	IDA	N benth	-
			Badel, 2006	16529372	-	IDA	N tab xanthi	-
			Badel, 2006	16529372	-	IDA	S lyco Money maker	-
positive regulation by symbiont of host defense-related PCD	GO:0034055	P	Alfano,2000	10781092	avrE (Pto PT23)	ISS	Glycine max	-
negative regulation by symbiont of defense-related host cell wall callose deposition	GO:0052202	P	Debroy, 2004	15210989	-	IDA	A thal Col-0	-
negative regulation by symbiont of host salicylic acid-mediated defense response	GO:0052004	P	Debroy,2004	15210989	-	IGI	A thal Col-0	-

avrPto (PSPTO_4001)

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GO term	GO ID	Ontology	Reference	PubMed ID	with	Evidence Code	Host ID	host interaction
host cell plasma membrane	GO:0020002	C	Shan, 2000	11148281	-	IDA	N tab W38	-
protein kinase binding	GO:0019901	F	Scofield, 1996	8953034	-	IPI	S lyco Rio Grande	binds Pto
			Xiang, 2008	18158241	-	IPI,IMP	A thal Col-0	binds FLs2
			Xiang, 2008	18158241	-	IPI	A thal Col-0	binds EFR
			Xiang, 2008	18158241	-	IPI, IMP	S lyco Money maker	binds LeFLS2
			Shan,2008	18621007	-	IPI	A thal	binds BAK1
pathogenesis	GO:0009405	P	Scofield, 1996	8953034	-	IDA	N benth	-
			Ronald, 1992	1537802	-	IDA	S lyco Rio Grande 76	-
			Hauck, 2003	12817082	-	IDA	A thal Col-0	-
interaction with host via protein secreted by type III secretion system	GO:0052049	P	Schechter, 2004	14702323	-	IDA	S lyco Money maker	-
	GO:0052049	P	Schechter, 2004	14702323	-	IDA	N benth	-
positive regulation of growth or development of symbiont during interaction with host	GO:0075339	P	Chang, 2000	10796023	AvrPto (Pto T1)	ISS	S lyco Rio Grande 76	-
	GO:0075339	P	Hauck, 2003	12817082	-	-	A thal Col-0	-
positive regulation by symbiont of host defense-related PCD	GO:0034055	P	Ronald, 1992	1537802	-	IDA	S lyco Rio Grande 76	-
negative regulation by symbiont of defense-related host callose deposition	GO:0052087	P	Hauck, 2003	12817082	-	IDA	A thal Col-0	reduces callose deposition induced by hrcC- DC3000
negative regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity	GO:0052034	P	He, 2006	16678099	-	IDA	A thal Col-0	reduces upregulation of FRK1, MPK3, MPK6 by flg22, HrpZ or NPP1
			Li,2005	16123135	-	IDA	A thal Col-0	reduces upregulation of NHO1 by flagellin
			Shan,2008	18621007	-	IDA	A thal	reduces upregulation of FRK1 by flg22, elf18, HrpZ, PGN, LPS, chitin, NPP!
negative regulation by symbiont of host defense-related protein level	GO:0033663	P	He, 2006	16678099	-	IDA	A thal Col-0	reduces upregulation of FRK1 by flg22, HrpZ or NPP1
	GO:0033663	P	Li,2005	16123135	-	IDA	A thal Col-0	reduces upregulation of NHO1 by flagellin
negative regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway	GO:0052078	P	He, 2006	16678099	-	IDA	A thal Col-0	reduces upregulation of MPK3, MPK6 by flg22, HrpZ or NPP1
negative regulation by symbiont of defense-related host reactive oxygen species production	GO:0033661	P	Hann&Rathjen, 2007	17217460	-	IDA	N benth	reduces upregulation of ROS by PtabF
modulation by symbiont of ethylene levels in host	GO:0052021	P	Cohn, 2005	16167902	-	IEP	S lyco Rio Grande	upregulates LeACO1 LeACO2
modulation by symbiont of host RNA levels	GO:0052018	P	Navarro, 2008	18703740	-	IDA	A thal Col-0	reduces miR39, miR171, miR173 levels

avrPtoB (hopAB2)

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GO term	GO ID	Ontology	Reference	PubMed ID	with	Evidence Code	Host ID	host interaction
host cell cytoplasm	GO:0030430	C	deVries, 2006	16367952	-	IDA	N benth	-
protein kinase binding	GO:0019901	F	Kim, 2002	12062102	-	IPI	S lyco Rio Grande	binds Pto
			Rosebrock, 2007	17637671	-	IPI	S pimp	binds Pto
			Rosebrock, 2007	17637671	-	IPI	S pimp	binds Fen
			Shan,2008	18621007	-	IPI	A thal	binds BAK1
protein binding	GO:0005515	F	Rosebrock, 2007	17637671	-	IPI	S pimp	binds PtoC
protein ubiquitination	GO:0016567	F	Rosebrock, 2007	17637671	-	IPI	S pimp	ubiquitinates Fen
ubiquitin-protein ligase activity	GO:0004842	F	Janjusevic, 2006	16373536	-	IDA	-	-
ubiquitin conjugating enzyme binding	GO:0031624	F	Janjusevic, 2006	16373536	-	IMP	-	-
ubiquitin conjugating enzyme binding	GO:0031624	F	Janjusevic, 2006	16373536	UniProt: P62877, Q8VZ40	ISS	-	-
pathogenesis	GO:0009405	P	Abramovitch, 2003	12505984	-	IDA	S lyco Rio Grande	-
			Jamir, 2004	14756767	-	IDA	N tab xanthi	-
			Jamir, 2004	14756767	-	IDA	A thal Ws-0	-
interaction with host via protein secreted by type III secretion system	GO:0052049	P	Kim,2002	12062102	-	IDA	S lyco Rio Grande	-
positive regulation of growth or development of symbiont during interaction with host	GO:0075339	P	He, 2006	16678099	-	IDA	A thal Col-0	-
	GO:0075339	P	Lin and Martin 2005	15672817	-	IDA	S lyco Rio Grande	-
negative regulation by symbiont of host molecular function	GO:0052056	P	Rosebrock, 2007	17637671	-	IDA	S pimp	reduces Fen function
positive regulation by symbiont of host defense-related PCD	GO:0034055	P	Kim,2002	12062102	-	IDA	S lyco Rio Grande	-
negative regulation by symbiont of host defense-related PCD	GO:0034054	P	Jamir, 2004	14756767	-	IDA	N tab xanthi	-
			Abramovitch, 2003	12505984	-	IDA	N benth	-
			Jamir, 2004	14756767	-	IDA	A thal Ws-0	-
			Janjusevic, 2006	16373536	-	IMP	S lyco	-
negative regulation by symbiont of host defense-related protein level	GO:0033663	P	Jamir, 2004	14756767	-	IDA	N tab xanthi	reduces upregulation of PR1a expression by HopA1
			Rosebrock, 2007	17637671	-	IDA	S lyco Rio Grande	degrades Fen (S pimp)
			He, 2006	16678099	-	IDA	A thal Col-0	reduces upregulation of FRK1 by flg22, HrpZ or NPP1
negative regulation by symbiont of host resistance gene-dependent defense response	GO:0033660	P	Abramovitch, 2003	12505984	-	IDA	N benth	reduces HR elicited by Avr9-Cf9 interaction
	GO:0033660	P	Abramovitch, 2003	12505984	-	IDA	S lyco Rio Grande	reduces HR elicited by AvrPto-Pto interaction
negative regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway	GO:0052078	P	He, 2006	16678099	-	IDA	A thal Col-0	reduces upregulation of MPK3, MPK6 by flg22, HrpZ or NPP1
negative regulation by symbiont of defense-related host reactive oxygen species production	GO:0033661	P	Hann&Rathjen, 2007	17217460	-	IDA	N benth	reduces upregulation of ROS by PtabF
negative regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity	GO:0052034	P	He, 2006	16678099	-	IDA	A thal Col-0	reduces upregulation of FRK1, MPK3, MPK6 by flg22, HrpZ or NPP1
modulation by symbiont of ethylene levels in host	GO:0052021	P	Cohn & Martin, 2005	16167902	-	IEP, IMP	S lyco Rio Grande	upregulates LeACO1 LeACO2
negative regulation by symbiont of host apoptosis	GO:0033668	P	Abramovitch, 2003	12505984	-	IDA	N benth	-
negative regulation by symbiont of host programmed cell death	GO:0052041	P	Abramovitch, 2003	12505984	-	IDA	S cerevisiae	-
modulation by symbiont of host RNA levels	GO:0052018	P	Navarro, 2008	18703740	-	IDA	A thal Col-0	reduces pri-miR393a and pri-miR393b levels